Salacia oblonga herb Extract

Salacia Oblonga (Celastaceae), "Ponkoranti", is a woody plant found in the forests of Sri Lanka and India. The roots and stems of Salacia Oblonga have been used extensively in Aryuveda and traditional Indian medicine for the treatment of Diabetes.

Recently, it has been found that a-Glucosidase inhibitors are potent therapeutic agents in carbohydrate-metabolic disorders such as Diabetes Mellitus.

Salacia Oblonga contains two potent a-Glucosidase inhibitors: Salicinol and Kotalanol 9. Methanol extracts from the roots of Salacia Oblonga exhibit an inhibitory effect on the increase of serum glucose levels in sucrose- and maltose-loaded rats. Salacia Oblonga has also been found to show inhibitory activity on Aldose Reductase which is related to such chronic diabetic complications as peripheral neuropathy, retinopathy, and cataracts.

Superior in terms of safety compared to chemically synthesized products, Salacia Oblonga is an effective anti-diabetic and dieting agent. Salacia Oblonga is more than 200 times stronger than Acarbose, an a-Glucosidase inhibitor manufactured by Bayer Corp.

In a study conducted by Kowsalya et at., it was determined that 2.5 to 5.0 grams of Salacia Oblonga daily is effective in lowering the blood glucose, serum cholesterol, triglycerides and increasing the HDL cholesterol levels of non-insulin dependent diabetes patients.

It is know that glucose absorbed in the body is converted into glycogens and neutral lipids by insulin and then accumulates as body fat and organ fat, thus causing obesity.

Salacia Oblonga inhibits the breakdown of oligosaccharides (disaccharides and trisaccharides) such as sucrose, maltose, etc. into monosaccharides and inhibits the absorption of monosaccharides such as glucose, mannose, etc. in the body, preventing blood sugar levels from rising.

The presence of S.oblonga extract tended to lower postprandial glycemia and significantly reduced the postprandial insulin response. The increase in breath hydrogen excretion suggests a mechanism similar to prescription alpha-glucosidase inhibitors.
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